2,2-Difluoroethanamine → HCID 86658103, compound

HRID 245494Notes

Reaction equation

HRID 245494 reaction equation
[Si]([O:18][CH2:19][C:20]1[C:21]([N:35]2[CH2:40][C@H:39]([CH3:41])[O:38][C@H:37]([CH3:42])[CH2:36]2)=[C:22]([F:34])[C:23]2[O:27][N:26]=[C:25]([C:28]([O:30]CC)=O)[C:24]=2[CH:33]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.[F:43][CH:44]([F:47])[CH2:45][NH2:46]>>[F:43][CH:44]([F:47])[CH2:45][NH:46][C:28]([C:25]1[C:24]2[CH:33]=[C:20]([CH2:19][OH:18])[C:21]([N:35]3[CH2:36][C@H:37]([CH3:42])[O:38][C@H:39]([CH3:41])[CH2:40]3)=[C:22]([F:34])[C:23]=2[O:27][N:26]=1)=[O:30]

Participants

3

Reactant 2

HCID 1362742,2-DifluoroethanamineHCID 67357675ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate2×

Product 1

HCID 86658103HCID 86658103, compound

Procedure

Starting materials: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate (Intermediate 204) and 2,2-difluoroethanamine

Sources & evidence

ORD record
ord-4825d9f570104737908e7bfcdf7aa4ba
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Reaction notes

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