HCID 67433810, compound → HCID 86658116, compound

Participants

Reaction Steps

(7-Chloro-6-((2R,6S)-2,6-dimethylmorpholino)-3-methylisoxazolo[4,5-b]pyridin-5-yl)methanol (Intermediate 352, 459 mg, 1.47 mmol) was dissolved in about 10 ml CH2Cl2. Manganese dioxide (1920 mg, 22.08 mmol) was added, and the slurry was stirred at room temperature for three days. The mixture was filtered through celite and concentrated. The crude was purified by chromatography on SiO2 using 10-30% EtOAc/hexanes. Recovered a yellow solid, 185 mg (41%).

Provenance & Evidence