反应详情

A solution of 3,4-difluoro-2-hydroxybenzoic acid (6.45 g, 37.05 mmol) and sulfuric acid (6 ml, 113 mmol) in MeOH (25 ml) was heated at reflux overnight. The mixture was diluted with water and extracted with ether. The ether was washed with aqueous NaHCO3, water and brine. The combined aqueous layers were twice more extracted with ether, which was washed with NaHCO3, water, and brine. The combined ether extracts were dried (MgSO4) and concentrated to give 6.4 g of product as a white solid.

1. temperatureat reflux overnight
2. extractionextracted with ether
3. washThe ether was washed with aqueous NaHCO3, water and brine
4. extractionThe combined aqueous layers were twice more extracted with ether, which
5. washwas washed with NaHCO3, water, and brine
6. dry with materialThe combined ether extracts were dried (MgSO4)
7. concentrationconcentrated