Barbituric Acid → HCID 67432928, compound

HRID 245564Notes

Reaction equation

HRID 245564 reaction equation
N1C(=O)CC(=O)NC1=O.F[C:11]1[C:28]([F:29])=[C:27]2[C:14]([CH2:15][C:16]3([C@H:25]4[C@H:33]([CH3:34])[O:32][C@H:31]([CH3:35])[CH2:30][N:26]42)[C:21](=[O:22])[NH:20][C:19](=[O:23])[NH:18][C:17]3=[O:24])=[CH:13][C:12]=1[C:36](=[N:43][OH:44])[C:37]1[CH:42]=[N:41][CH:40]=[CH:39][N:38]=1>>[F:29][C:28]1[C:11]2[O:44][N:43]=[C:36]([C:37]3[CH:42]=[N:41][CH:40]=[CH:39][N:38]=3)[C:12]=2[CH:13]=[C:14]2[C:27]=1[N:26]1[CH2:30][C@@H:31]([CH3:35])[O:32][C@@H:33]([CH3:34])[C@@H:25]1[C:16]1([C:21](=[O:22])[NH:20][C:19](=[O:23])[NH:18][C:17]1=[O:24])[CH2:15]2

Participants

3

Reactant 2

HCID 6211Barbituric AcidHCID 137195737HCID 137195737, compound2×

Product 1

HCID 67432928HCID 67432928, compound

Procedure

Barbituric acid and (2R,4S,4aS)-rel-9,10-difluoro-8-[(hydroxyimino)(pyrazin-2-yl)methyl]-2,4-dimethyl-1,2,4,4a-tetrahydro-2′H,6H-spiro[1,4-oxazino[4,3-a]quinoline-5,5′-pyrimidine]-2′,4′,6′(1′H,3′H)-trione (Intermediate 583) were reacted using a method similar to the one described for the synthesis of Example 8.

Workup

  1. customdescribed for the synthesis of Example 8

Sources & evidence

ORD record
ord-91088a069ffb4f47b0f1bc5324d59ec4
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Reaction notes

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