HRID245670

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)O[C@H]1CC[C@H](c2ncc3c(Cl)nccn32)CC1

HCID178476588

未命名化合物

结构：CC(=O)O[C@H]1CC[C@H](C(=O)NCc2nccnc2Cl)CC1

HCID178476598

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O[C@H]1CC[C@H](c2ncc3c(C)nccn32)CC1

HCID178476590

未命名化合物

收率 78.2%

PROCEDURE

实验过程

(Trans)-4-((3-chloropyrazin-2-yl)methylcarbamoyl)cyclohexyl acetate (2.8 g) was transformed into (trans)-4-(8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclohexyl acetate (2.2 g) using the procedure described in example 1 step 1b using a reaction temperature of 60° C. for 16 hours. Reaction of the latter compound (2.6 g) yielded (trans)-4-(8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl acetate (1.6 g) using the procedure described in example 2 step 2d.

WORKUP

后处理

customa reaction temperature of 60° C.
customfor 16 hours