4-methoxy-N-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-methyl-1H-indole-2-carboxamide → HCID 178487949, compound

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Reaction Steps

Using the procedure described in example 1 step 1f (trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl acetate (0.568 mmol, 200 mg) and 4-methoxy-N-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-methyl-1H-indole-2-carboxamide (0.568 mmol, 248 mg) gave after purification using column chromatography (silica gel; gradient heptanes/ethyl acetate 1/1 to ethyl acetate) the title compound (245 mg).

Provenance & Evidence