HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetoxyacetic acid → 2-((3-Chloropyrazin-2-yl)methylamino)-2-oxoethyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetoxyacetic acid | HCID 83766 | — |
| Reactant | (3-Chloropyrazin-2-yl)methanamine hydrochloride | HCID 42614233 | — |
| Product | 2-((3-Chloropyrazin-2-yl)methylamino)-2-oxoethyl acetate | HCID 86674647 | 90.3% |
Reaction Steps
According to the procedure described in example 13 step 13a acetoxyacetic acid (0.667 g) and 2-aminomethyl-3-chloropyrazine hydrochloride (content 77%; 0.81 g) gave 2-((3-chloropyrazin-2-yl)methylamino)-2-oxoethyl acetate (0.99 g) after purification by column chromatography (silica gel; gradient of dichloromethane to dichloromethane/ethyl acetate 1/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658794B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-c13c3b2d8fe947b4acaf0a37564f1b7a |
| Source note | uspto-grants-2014_02 |