HCID 67365110, compound → HCID 67364087, compound

Participants

Reaction Steps

Benzyl 3-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)azetidine-1-carboxylate (1.58 g) was dissolved in 37% hydrochloric acid (14.84 ml) and stirred at room temperature. After one hour the reaction mixture was concentrated in vacuo and coevaporated with toluene. Then the residue was dissolved in dichloromethane/methanol, 15 gram of Silica-carbonate (0.77 mmol/gram) was added and the suspension was stirred for 15 minutes. The suspension was filtered, the solids rinsed with methanol and the filtrate was concentrated in vacuo to give crude 3-(azetidin-3-yl)-1-bromo-8-methylimidazo[1,5-a]pyrazine (1.1 g).

Provenance & Evidence