Water → HCID 67363986, compound

Participants

Reaction Steps

To 1-bromo-8-methyl-3-(piperidin-4-yl)imidazo[1,5-a]pyrazine (0.447 mmol, 132 mg) in toluene (1 ml) and N,N-dimethylformamide (1 ml) were added triethylamine (0.894 mmol, 0.125 ml) and 2-chloro-N,N-dimethylacetamide (0.447 mmol, 0.046 ml). After stirring at room temperature for two hours water and dichloromethane were added, mixture was put on a phase separation filter and concentrated in vacuo. Purification by column chromatography (silica gel; dichloromethane with gradient 0 to 20% methanol) gave 2-(4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)piperidin-1-yl)-N,N-dimethylacetamide (100 mg).

Provenance & Evidence