Water → HCID 178495935, compound

Participants

Reaction Steps

To (trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)-N-(2-methoxyethyl)cyclohexanamine (0.182 mmol, 67 mg) in dichloromethane (2 ml) and triethylamine (0.912 mmol, 0.127 ml) at 0° C. was added acetyl chloride (0.274 mmol, 0.020 ml). After stirring for 1 hour dichloromethane and water were added. The organic layer was separated, dried over a phase separation filter and concentrated in vacuo to give N-((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)-N-(2-methoxyethyl)acetamide (72 mg).

Provenance & Evidence