Hydrochloric Acid → HCID 67364214, compound

Participants

Reaction Steps

Benzyl 4-(8-methylimidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate (3.71 mmol, 1.30 g) was dissolved in 37% hydrochloric acid (240 mmol, 20 ml). The reaction mixture was stirred at room temperature for two hours, then poured in water and washed twice with diethyl ether. The aqueous layer was concentrated in vacuo and co-evaporated with toluene and ethanol. The residue was dissolved in methanol and eluted twice over a column of Si-Carbonate (Silicycle, Loading 0.7 mmol/g) to give 8-methyl-3-(piperidin-4-yl)imidazo[1,5-a]pyrazine (0.93 g).

Provenance & Evidence