Acetic Acid → HCID 67364904, compound

Participants

Reaction Steps

8-Methyl-3-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)imidazo[1,5-a]pyrazine (0.303 mmol, 91 mg) was dissolved in dichloromethane (2 ml) and acetic acid (30.3 mmol, 1.734 ml). With stirring, bromine (0.303 mmol, 0.016 ml) in dichloromethane (0.2 mL) was added. After stirring at room temperature for one hour water was added and the mixture concentrated in vacuo. To the residue was added saturated aqueous sodium hydrogencarbonate and the mixture extracted twice with dichloromethane/methanol. The combined organic layers were concentrated in vacuo to yield 1-bromo-8-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)imidazo[1,5-a]pyrazine (88 mg).

Provenance & Evidence