HCID 67365154, compound → HCID 67364890, compound

Participants

Reaction Steps

To 8-methyl-3-(piperazin-1-yl)imidazo[1,5-a]pyrazine hydrochloride (299 mg) in methanol was added a small amount of Si-Carbonate (Silicycle, Loading 0.7 mmol/g) and the solvent was removed under vacuum. The residue was put on a column with Si-carbonate (3 g), eluted with dichloromethane/methanol (4:1) to give 8-methyl-3-(piperazin-1-yl)imidazo[1,5-a]pyrazine (196 mg). The latter compound (50 mg) was transformed into 1-(4-(4-(8-methylimidazo[1,5-a]pyrazin-3-yl)piperazin-1-yl)piperidin-1-yl)ethanone (99 mg) according to the procedure described in example 2 step 2b and purification by column chromatography (silica gel; gradient dichloromethane to dichloromethane/methanol 85/15).

Provenance & Evidence