HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-2-oxopiperidine-4-carboxylic acid → HCID 86674654, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-2-oxopiperidine-4-carboxylic acid | HCID 22265446 | — |
| Reactant | (3-Chloropyrazin-2-yl)methanamine hydrochloride | HCID 42614233 | — |
| Product | HCID 86674654 | HCID 86674654 | 62% |
Reaction Steps
2-Aminomethyl-3-chloropyrazine hydrochloride (content 77%; 5.36 mmol, 1.0 g) and 1-methyl-2-oxopiperidine-4-carboxylic acid (5.36 mmol, 0.843 g) were applied according to the procedure in example 13 step 13a and purified using column chromatography (silica gel; dichloromethane with 10% methanol) to give N-((3-chloropyrazin-2-yl)methyl)-1-methyl-2-oxopiperidine-4-carboxamide (940 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658794B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-253886c950ab4ce69832388fef5e53af |
| Source note | uspto-grants-2014_02 |