N-bromobutanimide → HCID 67363629, compound

Participants

Reaction Steps

To a solution of 1-methyl-4-(8-methylimidazo[1,5-a]pyrazin-3-yl)piperidin-2-one (0.205 mmol, 50 mg) in N,N-dimethylformamide (0.6 ml) was added N-bromosuccinimide (0.225 mmol, 40.1 mg) and the reaction mixture was stirred at room temperature for 15 minutes. Extraction dichloromethane/aqueous sodium hydrogen carbonate, drying (sodium sulfate) and concentrating in vacuo yielded the crude product. Purification by column chromatography (silica gel; dichloromethane with 10% methanol) yielded 4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)-1-methylpiperidin-2-one (46 mg).

Provenance & Evidence