Ethylenediamine → 2-(5-chloroindazol-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide

Participants

Reaction Steps

To a solution of 2-(5-chloro-indazol-1-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide (100 mg, 0.17 mmol) in CH2Cl2 (4 mL) was added TFA (2.0 mL, 26.0 mmol). The yellow reaction mixture was stirred at room temperature for 3 h then concentrated. The residue was redissolved in CH2Cl2 (4 mL) and ethylenediamine (0.4 mL, 5.92 mmol) was added. The reaction mixture was stirred at room temperature for 0.5 h then quenched with water and extracted with CH2Cl2 (3×). The combined organics were concentrated and the residue was triturated with EtOAc to afford 45 mg (58%) of 2-(5-chloroindazol-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-amide as a light yellow solid. MS: (M+Na)+=471; 1H NMR (DMSO-d6, 300 MHz): δ (ppm) 12.88 (s, 1H), 8.95 (s, 1H), 8.72 (dd, J=9.1, 4.5 Hz, 1H), 8.36-8.43 (m, 2H), 7.99-8.07 (m, 1H), 7.94 (d, J=1.9 Hz, 1H), 7.41-7.52 (m, 1H), 4.36-4.66 (m, 3H), 4.06-4.18 (m, 1H), 3.94-4.04 (m, 1H), 3.66-3.81 (m, 1H), 1.26 (t, J=6.0 Hz, 3H).

Provenance & Evidence