Hydrochloric Acid → HCID 178464536, compound

Participants

Reaction Steps

To a solution of 2-methyl-propane-2-sulfinic acid {1-[cis-3-(tert-butyl-dimethyl-silanyloxy)-cyclobutyl]-ethyl}-amide (200 mg, 0.60 mmol) in MeOH (3 mL) was added hydrogen chloride (4.0M in 1,4-dioxane, 0.30 mL, 1.2 mmol). The reaction mixture was stirred at room temperature for 20 min then concentrated to afford cis-3-(1-aminoethyl)-cyclobutanol hydrochloride as an off-white semisolid which was used without further purification. 1H NMR (METHANOL-d4, 300 MHz): δ (ppm) 4.09 (quind, J=7.5, 3.8 Hz, 1H), 3.17 (dt, J=6.0, 3.0 Hz, 1H), 2.36-2.56 (m, 2H), 1.78-1.96 (m, 1H), 1.59-1.77 (m, 2H), 1.22 (dd, J=6.8, 3.8 Hz, 3H).

Provenance & Evidence