4-Nitrobenzenesulfonyl chloride → HCID 178429795, compound

Participants

Reaction Conditions

Reaction Steps

4-Nitrobenzene-1-sulfonyl chloride (6.9 g, 31 mmol) was dissolved in acetonitrile (8 ml) and stirred in an ice bath. A solution of (R)-2-aminopropan-1-ol (1 g, 13.3 mmol) in pyridine (5 ml) was added slowly and the reaction was stirred for 2 h. Ethyl acetate (25 ml) and water (10 ml) were added and the reaction was stirred for 10 min. The layers were separated and the organic layer was washed with 1M citric acid solution twice and with water once. The organic layer was cooled to 10° C. and 7 ml of water was added followed by dropwise addition of N,N-diisopropylethylamine (3.7 ml, 21.3 mmol). After stirring for 1 h the layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organics were washed twice with 1M citric acid solution and twice with water. Isopropanol (70 ml) was then added and the solvents were evaporated slowly leaving mostly isopropanol. (R)-2-Methyl-1-(4-nitro-benzenesulfonyl)-aziridine 2.2 g (69%) was obtained after crystallization from isopropanol. 1H NMR (300 MHz, CDCl3) δ: 8.40 (d, J=9.1 Hz, 2H), 8.16 (d, J=9.1 Hz, 2H), 2.92-3.04 (m, 1H), 2.74 (d, J=7.2 Hz, 1H), 2.13 (d, J=4.5 Hz, 1H), 1.30 (d, J=5.7 Hz, 3H).

Provenance & Evidence