HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate | HCID 67324694 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate | HCID 71280724 | — |
Reaction Steps
(S)-(Tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester (42 mg, 0.21 mmol) was dissolved in dichloromethane (2.2 ml) and cooled in an ice bath. Trifluoroacetic acid (1.2 ml) was slowly added and the reaction was stirred at room temperature for 3 h then evaporated and dried under high vacuum to afford (S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658646B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-fff9c8c54d0e477aaaac4c38aa4d05de |
| Source note | uspto-grants-2014_02 |