Methyl iodide → 2-(6-chloro-4-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-methoxy-1-methyl-ethyl)-amide

Participants

Reaction Conditions

Reaction Steps

A 50 mL round-bottomed flask was charged with 2-(6-chloro-4-fluoro-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-methoxy-1-methyl-ethyl)-amide (120 mg, 0.225 mmol) and DMF (0.45 ml) to give a light yellow solution. The reaction mixture was placed under argon atmosphere and cooled in a 0° C. bath. NaH (60% in mineral oil, 23 mg, 0.575 mmol) was added. The reaction mixture was stirred at 0° C. for 10 min and at room temperature for 10 min then returned to the cooling bath and iodomethane (21 μl, 0.34 mmol) was added. The reaction was stirred at 0° C. for 10 min then the bath was removed and stirring continued at room temperature for an additional 18 h. The reaction was quenched with water and the precipitate collected by filtration. The crude material was purified by chromoatography over SiO2 with EtOAc/heptane (gradient: 0-100% EtOAc) to afford 41 mg (33%) of 2-(6-chloro-4-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-methoxy-1-methyl-ethyl)-amide as an off-white solid. MS: [M+H]+=547.

Provenance & Evidence