Trifluoroacetic acid → 1-((R)-2-amino-3-methoxy-propionyl)-azetidine-3-carbonitrile trifluoroacetate

Participants

Reaction Conditions

Reaction Steps

In a 25 mL round-bottomed flask, [(R)-2-(3-cyano-azetidin-1-yl)-1-methoxymethyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (286 mg, 1.00 mmol) was dissolved in dichloromethane (4 ml). The reaction was cooled to 0° C. and trifluoroacetic acid (1.2 ml, 15.6 mmol) was slowly added. The reaction mixture was stirred at room temperature for 3 h then concentrated to provide 1-((R)-2-amino-3-methoxy-propionyl)-azetidine-3-carbonitrile trifluoroacetate as a colorless viscous oil which was used without further purification.

Provenance & Evidence