Sodium Hydroxide → [[4-(3-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl]-(3-phenyl-2-propene-1-yl)-amino]acetic acid

HRID 24621Notes

Reaction equation

HRID 24621 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([N:16]([CH2:26][C:27]([O:29]C)=[O:28])[CH2:17][CH:18]=[CH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:15])=[C:12]([CH3:31])[NH:11][C:10](=[O:32])[NH:9]2)[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([N:16]([CH2:26][C:27]([OH:29])=[O:28])[CH2:17][CH:18]=[CH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:15])=[C:12]([CH3:31])[NH:11][C:10](=[O:32])[NH:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 73704953Methyl [[4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl]-(3-phenyl-2-propene-1-yl)-amino]acetate

Product 1

HCID 69746317[[4-(3-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl]-(3-phenyl-2-propene-1-yl)-amino]acetic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

100 mg (0.220 mmol) of methyl [[4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl]-(3-phenyl-2-propene-1-yl)-amino]acetate was dissolved in 2 ml of methanol. 0.480 ml of 1 N aqueous sodium hydroxide solution was added to the obtained solution, and they were stirred at room temperature overnight. The solvent was evaporated under reduced pressure, and the residue was washed with water. After the slurry washing, the title compound was obtained.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with water
  3. washAfter the slurry washing

Sources & evidence

ORD record
ord-e8d723aa22754fbd82d497d993a7ac9e
Source dataset
uspto-grants-2005_02
Patent number
US06855716B2

Reaction notes

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