HCID 86677955, compound → HCID 62386834, compound

HRID 246211Notes

Reaction equation

HRID 246211 reaction equation
[N+:1]([CH:4]([CH3:13])[CH:5]([CH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)[OH:6])([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][CH:4]([CH3:13])[CH:5]([CH:7]1[CH2:8][CH2:9][O:10][CH2:11][CH2:12]1)[OH:6]

Participants

5

Reactant 2

HCID 86677955HCID 86677955, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 62386834HCID 62386834, compoundYield 91.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-Nitro-1-(tetrahydro-pyran-4-yl)-propan-1-ol (1.3 g, 6.87 mmol) was dissolved in ethanol (55 mL) and treated with palladium on carbon (0.2 g) under 1 atm of hydrogen. After stirring at room temperature overnight, the palladium was filtered off and the solvent reduced under reduced pressure to provide 1.0 g (91%) of 2-amino-1-(tetrahydro-pyran-4-yl)-propan-1-ol.

Workup

  1. filtrationthe palladium was filtered off

Sources & evidence

ORD record
ord-853d6c5c9b9b439792f49637fa722921
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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