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0 °C

2-(6-Fluoro-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-methoxy-1-methyl-ethyl)-amide (80 mg, 0.16 mmol) was combined with DMF (8 mL) at 0° C. to give a yellow solution. Sodium hydride (60% in mineral oil, 19 mg, 0.48 mmol) was added and the reaction was stirred at 0° C. for 10 min. 4-(5-(Chloromethyl)pyridin-2-yl)morpholine hydrochloride (60 mg, 0.24 mmol) was added and the reaction mixture was stirred at 0° C. for 30 min then warmed to room temperature and stirred for 2 h. The reaction mixture was quenched with 5 mL of brine and 10 mL of water and extracted with ethyl acetate (2×30 mL). The combined organic layers were washed with water and brine then dried and concentrated in vacuo. The crude material was purified by silica gel chromatography (0-10% methanol in dichloromethane) to afford 58 mg (53%) of 2-[6-fluoro-1-(6-morpholin-4-yl-pyridin-3-ylmethyl)-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-methoxy-1-methyl-ethyl)-amide as a foaming solid. MS: (M+H)+=675.

1. customto give a yellow solution
2. stirringthe reaction mixture was stirred at 0° C. for 30 min
3. temperaturethen warmed to room temperature
4. stirringstirred for 2 h
5. customThe reaction mixture was quenched with 5 mL of brine and 10 mL of water
6. extractionextracted with ethyl acetate (2×30 mL)
7. washThe combined organic layers were washed with water and brine
8. customthen dried
9. concentrationconcentrated in vacuo
10. customThe crude material was purified by silica gel chromatography (0-10% methanol in dichloromethane)