Diisopropylethylamine → HCID 71285812, compound

Participants

Reaction Steps

In a round-bottomed flask, 2-(1-amino-cyclobutyl)-propan-2-ol trifluoroacetate (214 mg, 0.62 mmol) was dissolved in DMF (1.2 ml) and N,N-diisopropylethylamine (0.44 ml, 2.52 mmol). Then 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (110 mg, 0.25 mmol) and HATU (104 mg, 0.27 mmol) were added. The yellow reaction mixture was stirred at room temperature overnight then water and petroleum ether were added. The resulting precipitate was collected by filtration. The filter cake was washed with water and petroleum ether then dried under high vacuum to afford 142 mg (98%) of 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [1-(1-hydroxy-1-methyl-ethyl)-cyclobutyl]-amide as an off-white powder.

Provenance & Evidence