Iodine → HCID 178519424, compound

Participants

Reaction Steps

In a round-bottomed flask, (1H-indazol-7-yl)-methanol (572 mg, 3.09 mmol) was dissolved in DMF (8 ml) and potassium hydroxide (671 mg, 12.0 mmol) and iodine (1.57 g, 6.18 mmol) were added. The dark brown suspension was stirred at room temperature overnight then quenched with aqueous 10% Na2S2O3 and extracted with diethyl ether (2×). The combined organic layers were washed twice with water and once with brine then dried over sodium sulfate, filtered and concentrated to give 433 mg (51%) of (3-iodo-1H-indazol-7-yl)-methanol as a light yellow solid.

Provenance & Evidence