Iodine → HCID 178458234, compound

Participants

Reaction Steps

In a round-bottomed flask, 2-(1H-indazol-7-yl)-propan-2-ol (204 mg, 1.16 mmol) was dissolved in DMF (3 ml) and iodine (588 mg, 2.32 mmol) and potassium hydroxide (251 mg, 4.48 mmol) were added. The dark brown suspension was stirred at room temperature for 5 h then quenched with 10% aqueous NaHSO3 and extracted with a mixture of diethyl ether and EtOAc (2×). The combined organic layers were washed twice with water and once with brine then dried over sodium sulfate, filtered and concentrated to afford 2-(3-iodo-1H-indazol-7-yl)-propan-2-ol as a light yellow oil which was used without further purification.

Provenance & Evidence