Imidazole → HCID 178460605, compound

Participants

Reaction Steps

In a round-bottomed flask, 2-(3-iodo-1H-indazol-7-yl)-propan-2-ol (crude from Step 2, 479 mg, 1.11 mmol) was dissolved in DMF (3.2 ml) and imidazole (189 mg, 2.77 mmol) and trimethylsilyl chloride (0.17 ml, 1.33 mmol) were added. The reaction mixture was stirred at room temperature overnight then quenched with water and extracted with diethyl ether (2×). The combined organic layers were washed twice with water and once with brine then dried over sodium sulfate, filtered and concentrated to give 383 mg (88%) of 3-iodo-7-(1-methyl-1-trimethylsilanyloxy-ethyl)-1H-indazole as a light yellow solid. 1H NMR (CDCl3, 300 MHz): δ (ppm) 10.86 (br. s., 1H), 7.40 (dd, J=6.8, 2.3 Hz, 1H), 7.12-7.21 (m, 2H), 1.73 (s, 6H), 0.11 (s, 9H).

Provenance & Evidence