2-bromo-N-isopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide → N-isopropyl-2-(1,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Participants

Reaction Conditions

Reaction Steps

2-Bromo-N-isopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (107 mg, 259 μmol) and 1,6,6-trimethyl-3-(tributylstannyl)-4,5,6,7-tetrahydro-1H-indazole (see Example 70, 188 mg, 414 μmol.6) were dissolved in DMF (2.5 mL) under argon, tetrakis(triphenylphosphine)palladium (0) (15.0 mg, 12.9 μmol) and CuI (4.64 mg, 51.8 μmol, Eq: 0.20) were added and the mixture sonicated for 5 min with bubbling argon. The reaction mixture was stirred at 90° C. (oil bath temperature) for 2.5 h. The reaction mixture was concentrated under high vacuum and the residue was purified by chromatography (silica, 40 g column, 50 μm from Analogix, 0-50% EtOAc in hexanes over 15 min) to give N-isopropyl-2-(1,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (90 mg, 181 μmol, 70.0%) as a light yellow solid and of approximately 75% purity. MS (M+H)+=497.1; 1H NMR (CDCl3) δ: 9.10 (s, 1H), 8.26 (s, 1H), 8.18 (d, J=7.9 Hz, 1H), 5.68 (s, 2H), 4.34-4.60 (m, 1H), 3.82 (s, 3H), 3.48-3.61 (m, 2H), 3.03 (t, J=6.2 Hz, 2H), 2.41 (s, 2H), 1.61 (t, J=6.4 Hz, 2H), 1.33 (d, J=6.8 Hz, 6H), 1.09 (s, 6H), 0.83-0.97 (m, 2H), −0.06 (s, 9H). NMR and LCMS showed an impurity that was identified as the dimer of the tetrahydroindazole (MW 326.49) linked at the 3-position.

Provenance & Evidence