2-bromo-N-isopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide → 2-(5-(3-chlorophenoxy)-1-methyl-1H-indazol-3-yl)-N-isopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

HRID 246362Notes

Reaction equation

HRID 246362 reaction equation
Br[C:2]1[N:3]=[C:4]2[C:10]([C:11]([NH:13][CH:14]([CH3:16])[CH3:15])=[O:12])=[CH:9][N:8]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[C:5]2=[N:6][CH:7]=1.[Cl:25][C:26]1[CH:27]=[C:28]([CH:53]=[CH:54][CH:55]=1)[O:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[N:35]([CH3:39])[N:34]=[C:33]2[Sn](CCCC)(CCCC)CCCC>CN(C=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Cu]I>[Cl:25][C:26]1[CH:27]=[C:28]([CH:53]=[CH:54][CH:55]=1)[O:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[N:35]([CH3:39])[N:34]=[C:33]2[C:2]1[N:3]=[C:4]2[C:10]([C:11]([NH:13][CH:14]([CH3:16])[CH3:15])=[O:12])=[CH:9][N:8]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[C:5]2=[N:6][CH:7]=1

Participants

6

Reactant 2

HCID 585222792-bromo-N-isopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideHCID 712795465-(3-chlorophenoxy)-1-methyl-3-(tributylstannyl)-1H-indazole

Product 1

HCID 712795452-(5-(3-chlorophenoxy)-1-methyl-1H-indazol-3-yl)-N-isopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideYield 77%

Reagents, catalysts & solvents 3

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 178418397HCID 178418397, compoundCatalystHCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

2-Bromo-N-isopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (103 mg, 250 μmol) and 5-(3-chlorophenoxy)-1-methyl-3-(tributylstannyl)-1H-indazole (219 mg, 400 μmol.6) were dissolved in DMF (2.5 mL) under argon, tetrakis(triphenylphosphine)palladium (0) (14.4 mg, 12.5 μmol) and CuI (9.52 mg, 50.0 μmol, Eq: 0.20) were added and the mixture sonicated for 5 min with bubbling argon. The reaction mixture was stirred at 90° C. (oil bath temperature) for 2.5 h. The reaction mixture was concentrated under high vacuum and the residue was purified by chromatography (40 g column, 50 μm from Analogix, 0-50% over 30 min) to give 2-(5-(3-chlorophenoxy)-1-methyl-1H-indazol-3-yl)-N-isopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (113 mg, 191 μmol, 77%) as a light yellow solid. 1H NMR (CDCl3) δ: 9.27 (s, 1H), 8.32 (s, 1H), 8.28 (d, J=2.3 Hz, 1H), 8.05 (d, J=8.3 Hz, 1H), 7.52 (d, J=8.7 Hz, 1H), 7.17-7.28 (m, 2H), 6.97-7.06 (m, 1H), 6.79-6.90 (m, 2H), 5.71 (s, 2H), 4.28-4.46 (m, 1H), 4.23 (s, 3H), 3.51-3.66 (m, 2H), 1.22 (d, J=6.4 Hz, 6H), 0.85-1.03 (m, 2H), −0.04 (s, 9H).

Workup

  1. customthe mixture sonicated for 5 min with bubbling argon
  2. concentrationThe reaction mixture was concentrated under high vacuum
  3. customthe residue was purified by chromatography (40 g column, 50 μm from Analogix, 0-50% over 30 min)

Sources & evidence

ORD record
ord-a565caedc43f40caa69c60bb5735243b
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

Loading…