Tributyltin Chloride → 5-(difluoromethoxy)-3-(tributylstannyl)-1H-indazole

Participants

Reaction Conditions

Reaction Steps

5-(Difluoromethoxy)-3-iodo-1H-indazole (0.175 g, 564 μmol) was dissolved in THF (3 mL). The colorless solution was cooled to −16° C. (NaCl/ice bath), isopropylmagnesium chloride 2M in THF (621 μL, 1.24 mmol.2) was added dropwise at −16° C. The reaction mixture was stirred at −16° C. for 20 min. Then, tributylchlorostannane (220 mg, 184 μL, 677 μmol.2) was added slowly. The reaction mixture was warmed to 25° C. and stirred for 1.5 h. The reaction mixture was quenched with saturated ammonium chloride solution, extracted with dichloromethane (3×30 mL), organics dried over MgSO4 and concentrated to a yellow oil. The residue was dried under high vacuum and taken into next step without further purification yielding 5-(difluoromethoxy)-3-(tributylstannyl)-1H-indazole, crude mass exceeded yield, assumed quantitative.

Provenance & Evidence