2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde → 2-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

2-Bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde (406 mg, 1.14 mmol) and 1-methyl-3-(tributylstannyl)-4,5,6,7-tetrahydro-1H-indazole (485 mg, 1.14 mmol) were dissolved in DMF (3.00 mL) under argon, tetrakis(triphenylphosphine)palladium (0) (65.9 mg, 57.0 μmol) and CuI (43.4 mg, 228 μmol, Eq: 0.20) were added and the mixture sonicated for 5 min with bubbling argon. The reaction mixture was stirred at 90° C. (oil bath temperature) for 18 h. The reaction mixture was concentrated under high vacuum and the dark yellow solid residue was purified by chromatography (80 g column, 50 μm from SiliCycle) gradient 0-50% EtOAc in hexanes over 30 min) to give 2-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde (265 mg, 644 μmol, 56.5%) as a light yellow solid. MS (M+H)+=412; 1H NMR (CDCl3) δ: 10.50 (s, 1H), 9.07 (s, 1H), 8.29 (s, 1H), 5.77 (s, 2H), 3.89 (s, 3H), 3.57-3.72 (m, 2H), 3.05 (t, J=6.0 Hz, 2H), 2.69 (t, J=6.0 Hz, 2H), 1.80-2.02 (m, 4H), 0.92-1.09 (m, 2H), 0.00 (s, 9H).

Provenance & Evidence