Isopropylamine → 3-(7-(isopropylcarbamoyl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazole 2-oxide

Participants

Reaction Conditions

Reaction Steps

In a 16×100 mm screw cap test tube were added HATU (46.3 mg, 122 μmol.20) and propan-2-amine (24.0 mg, 406 μmol) then 3-(7-carboxy-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazole 2-oxide (45 mg, 101 μmol) dissolved in dichloromethane (2.50 mL) was added to give a light yellow solution which immediately formed a white precipitated. The reaction mixture stirred at 25° C. overnight, solvents evaporated and residue purified by chromatography (spherical silica 20-45 μm, 23 g, Versaflash Supelco) eluting with 0 to 50% EtOAc in hexanes over 30 min to yield 3-(7-(isopropylcarbamoyl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazole 2-oxide (45 mg, 92.8 μmol, 91.5%) as a clear foam. MS (M+H)+=485.1 (100% purity); 1H NMR (CDCl3) δ: 7.91 (s, 1H), 6.41 (d, J=8.1 Hz, 1H), 6.11 (s, 1H), 4.54 (s, 2H), 3.22-3.37 (m, 1H), 2.36-2.46 (m, 2H), 2.31 (s, 3H), 1.22-1.44 (m, 2H), 1.00-1.14 (m, 2H), 0.82-1.00 (m, 4H), 0.16 (d, J=6.6 Hz, 7H), −0.30-−0.12 (m, 2H), −1.19 (s, 9H).

Provenance & Evidence