Tributyltin Chloride → HCID 71279802, compound

Participants

Reaction Conditions

Reaction Steps

1-(2-(1,3-dioxan-2-yl)ethyl)-5-(difluoromethoxy)-3-iodo-1H-indazole (242 mg, 571 mmol) was dissolved in THF (3.00 mL). The colorless solution was cooled to −16° C. (NaCl/ice bath), isopropylmagnesium chloride 2M in THF (319 μL, 639 μmol) was added dropwise at −16° C. The reaction mixture was stirred at −16° C. for 20 min. Then, tributylchlorostannane (214 mg, 178 μL, 656 μmol) was added slowly. The reaction mixture was warmed to 25° C. and stirred for 1.5 h. The reaction mixture was quenched with saturated ammonium chloride solution, extracted with dichloromethane (3×30 mL), organics dried over MgSO4 and concentrated to a yellow oil. The residue was dried under high vacuum and taken into next step without further purification yielding 1-(2-(1,3-dioxan-2-yl)ethyl)-5-(difluoromethoxy)-3-(tributylstannyl)-1H-indazole, assumed quantitative and used into the next step without further purification.

Provenance & Evidence