Trifluoroacetic acid → HCID 71280056, compound

Participants

Reaction Conditions

Reaction Steps

N-tert-Butyl-2-(1-(2-(dimethylamino)ethyl)-6-fluoro-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (0.085 g, 153 μmol) was placed in a sealed tube and dissolved in dichloromethane (2 mL). Trifluoroacetic acid (1.75 g, 1.18 mL, 15.3 mmol) was added and the tube sealed and the mixture heated at to 80° C. After 15 h the mixture was cooled and then concentrated in vacuo. The residue was crystallized from dichloromethane/methanol and cyclohexane to give N-tert-butyl-2-(1-(2-(dimethylamino)ethyl)-6-fluoro-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (38 mg, 89.7 μmol, 58.5%) as a white powder. MS (M+H)+=424; 1H NMR (CDCl3) δ: 9.07 (s, 1H), 8.42-8.50 (m, 1H), 8.24 (s, 1H), 7.33-7.41 (m, 1H), 7.02 (s, 1H), 4.88 (s, 2H), 3.68-3.79 (m, 2H), 2.85 (s, 7H), 1.55 (s, 6H).

Provenance & Evidence