反应详情

温度

80 °C

N-tert-Butyl-2-(6-fluoro-1-(2-morpholino-2-oxoethyl)-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (42 mg, 68.9 μmol) was placed in a sealed tube and dissolved in dichloromethane (2 mL). Trifluoroacetic acid (785 mg, 531 μL, 6.89 mmol) was added and the tube was sealed and the mixture heated at to 80° C. After 15 h the mixture was cooled and concentrated in vacuo. Recrystallization from dichloromethane/methanol and cyclohexane gave 2-(6-fluoro-1-(2-morpholino-2-oxoethyl)-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (7 mg, 16.5 μmol, 24.0%) as a white powder. MS (M−H)−=422; 1H NMR (DMSO-d6) δ: 8.42 (s, 1H), 7.72 (dd, J=8.9, 5.1 Hz, 1H), 7.65 (s, 1H), 6.73 (d, J=9.4 Hz, 1H), 6.37-6.47 (m, 1H), 4.82 (s, 2H), 2.89-3.09 (m, 6H), 2.82 (d, J=4.9 Hz, 2H).

1. customthe tube was sealed
2. temperatureAfter 15 h the mixture was cooled
3. concentrationconcentrated in vacuo
4. customRecrystallization from dichloromethane/methanol and cyclohexane