Trifluoroacetic acid → HCID 71280381, compound

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Reaction Steps

To a stirred solution of N-tert-butyl-2-(5-fluoro-1H-indazol-1-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (120 mg, 249 μmol) in dichloromethane (3 mL) was added trifluoroacetic acid (1 mL). After 15 h, the mixture was concentrated in vacuo then 25 mL Jan. 10, 1960 of a solution of ammonium hydroxide/methanol/dichloromethane was added. After 1 h the mixture was concentrated in vacuo then purified by chromatography (silica, 24 g Analogix column, 0-5% methanol containing 10% ammonium hydroxide in dichloromethane) to give 2-(5-fluoro-indazol-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide (24.4 mg, 28%). MS: (M+H)+=353; 1H NMR (DMSO-d6) δ: 9.02 (s, 1H), 8.56-8.61 (m, 2H), 8.53 (d, J=0.8 Hz, 2H), 8.42 (d, J=3.0 Hz, 1H), 7.78 (dd, J=8.8, 2.3 Hz, 1H), 7.62 (s, 1H), 7.49 (d, J=2.5 Hz, 1H), 1.50 (s, 9H).

Provenance & Evidence