Trifluoroacetic acid → HCID 71279812, compound

Participants

Reaction Steps

To a stirred solution of N-tert-butyl-2-(6-methyl-1H-indazol-1-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (100 mg, 209 μmol) in dichloromethane (3 mL) was added trifluoroacetic acid (1 mL). After 15 h, the mixture was concentrated in vacuo then 25 mL of a Jan. 10, 1960 mixture of ammonium hydroxide/methanol/dichloromethane added. After 1 h the mixture was concentrated in vacuo. Purification by chromatography (silica, 24 g Analogix column, 0-4% methanol containing 10% ammonium hydroxide in dichloromethane, 15 min gradient) gave 2-(6-methyl-indazol-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide (35 mg, 48%). MS (M+H)+=349; 1H NMR (DMSO-d6) δ: 8.95 (s, 1H), 8.45 (d, J=0.8 Hz, 1H), 8.41 (s, 1H), 8.29 (s, 1H), 7.84 (d, J=8.3 Hz, 1H), 7.71 (s, 1H), 7.21 (dd, J=8.3, 0.8 Hz, 1H), 2.53 (s, 3H), 1.49 (s, 9H).

Provenance & Evidence