Cesium carbonate → tert-butyl 3-((3-(7-(tert-butylcarbamoyl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)-5-(difluoromethoxy)-1H-indazol-1-yl)methyl)azetidine-1-carboxylate

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N-tert-Butyl-2-(5-(difluoromethoxy)-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (152 mg, 286 μmol), tert-butyl 3-(iodomethyl)azetidine-1-carboxylate (85.1 mg, 286 μmol) and cesium carbonate (280 mg, 859 μmol) in dimethylformamide (3 mL) were heated in a microwave at 150° C. for 30 min. The mixture was partitioned between ethyl acetate and water, washed with water, dried and concentrated in vacuo. Purification by chromatography (silica, 24 g Analogix column, 0-40% ethyl acetate in hexanes) gave tert-butyl 3-((3-(7-(tert-butylcarbamoyl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)-5-(difluoromethoxy)-1H-indazol-1-yl)methyl)azetidine-1-carboxylate that was used directly without purification. MS (M+H)+=702.

Provenance & Evidence