Cesium carbonate → 5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of N-tert-butyl-2-(5-(difluoromethoxy)-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (117.1 mg, 221 μmol) and (bromomethyl)cyclopropane (386 mg, 250 μL, 2.86 mmol) in DMF (60 mL) under Ar, cesium carbonate (750 mg, 2.3 mmol) was added in a single portion. The reaction mixture was stirred at 70° C. After 18 h, the reaction was cooled to 25° C. and quenched with water (200 mL). The mixture was extracted with ethyl acetate (3×75 mL) and the organics were washed with brine (100 mL). The organics were dried over sodium sulfate and concentrated to give N-tert-butyl-2-(1-(cyclopropylmethyl)-5-(difluoromethoxy)-1H-indazol-3-yl)-5-(2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (120 mg, 205 μmol, 86%). MS (M)'=585; 1H NMR (DMSO-d6) δ: 9.14 (s, 1H), 8.59 (s, 1H), 8.20 (d, J=2.0 Hz, 1H), 7.93 (s, 1H), 7.87 (s, 1H), 7.41 (dd, J=2.0, 8.8 Hz, 1H), 7.21 (t, J=74.3 Hz, 1H), 5.86 (m, 1H), 5.07 (dd, J=1.5, 17.1 Hz, 1H), 4.98 (d, J=10.3 Hz, 1H), 4.64 (t, J=7.0 Hz, 2H), 3.58 (t, J=8.0 Hz, 2H), 2.70 (m, 2H), 1.51 (s, 9H), 0.86 (t, J=8.0 Hz, 2H), −0.08 (s, 9H).

Provenance & Evidence