Trifluoroacetic acid → HCID 71280309, compound

Participants

Reaction Steps

To a stirred solution of N-tert-butyl-2-(5-(difluoromethoxy)-1-(2-(methylamino)-2-oxoethyl)-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (69.0 mg, 115 μmol) in dichloromethane (3.00 mL) under Ar, trifluoroacetic acid (372 mg, 0.25 mL, 3.26 mmol) was added at 25° C. After 18 h, the solvent was removed and the residue was dissolved in a mix of dichloromethane/methanol/NH3OH (3:2:0.25, 5.25 mL) and stirred. After 2.5 h, the reaction was concentrated and dried in vacuo (200 mTorr, 25° C.). The solid residue was triturated with water (50 mL) and isolated by filtration. The solid was washed with water and hexanes and dried in vacuo (200 mTorr, 40° C.) to give N-tert-butyl-2-(5-(difluoromethoxy)-1-(2-(methylamino)-2-oxoethyl)-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (45.6 mg, 91.9 μmol, 80%) as a light brown solid. MS (M)'=472; 1H NMR (DMSO-d6) δ: 12.83 (br. s, 1H), 9.04 (s, 1H), 8.39 (d, J=2.8 Hz, 1H), 8.21 (m, 2H), 7.89 (s, 1H), 7.81 (d, J=9.0 Hz, 1H), 7.40 (dd, J=2.0, 9.0 Hz, 1H), 7.20 (t, J=74.3 Hz, 1H), 5.24 (s 2H), 2.65 (m, 3H), 1.51 (s, 9H).

Provenance & Evidence