Trifluoroacetic acid → N-tert-butyl-2-(6-fluoroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

HRID 246551Notes

Reaction equation

HRID 246551 reaction equation
[C:1]([NH:5][C:6]([C:8]1[C:16]2[C:11](=[N:12][CH:13]=[C:14]([C:17]3[N:18]=[CH:19][N:20]4[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=34)[N:15]=2)[N:10](COCC[Si](C)(C)C)[CH:9]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C(O)=O>ClCCl>[C:1]([NH:5][C:6]([C:8]1[C:16]2[C:11](=[N:12][CH:13]=[C:14]([C:17]3[N:18]=[CH:19][N:20]4[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=34)[N:15]=2)[NH:10][CH:9]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71280199N-tert-butyl-2-(6-fluoroimidazo[1,5-a]pyridin-1-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Product 1

HCID 71279458N-tert-butyl-2-(6-fluoroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideYield 92.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of N-tert-butyl-2-(6-fluoroimidazo[1,5-a]pyridin-1-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (95 mg, 197 μmol) in dichloromethane (3 mL) was added trifluoroacetic acid (449 mg, 303 μL, 3.94 mmol) at room temperature. After 16 h the reaction was concentrated. The residue was dissolved in dichloromethane (3 mL), methanol (1.5 mL) and ammonium hydroxide (0.45 mL). After 1 h the reaction was concentrated. The residue was triturated with water and filtered. The solid was washed water and ether then dried under vacuum to give N-tert-butyl-2-(6-fluoroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (64 mg, 182 μmol, 92%) as a yellow solid. MS: (M+H)+=353; 1H NMR (CD3OD) δ: 9.10 (s, 1H), 8.48 (d, J=5.1 Hz, 1H), 8.45 (s, 1H), 8.42 (m, 1H), 8.25 (s, 1H), 7.03 (m, 1H), 1.62 (s, 9H).

Workup

  1. concentrationAfter 16 h the reaction was concentrated
  2. dissolutionThe residue was dissolved in dichloromethane (3 mL)
  3. concentrationAfter 1 h the reaction was concentrated
  4. customThe residue was triturated with water
  5. filtrationfiltered
  6. washThe solid was washed water and ether
  7. customthen dried under vacuum

Sources & evidence

ORD record
ord-65715461a1f1424d90677888c63ead7f
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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