Ethylenediamine → HCID 71279811, compound

Participants

Reaction Conditions

Reaction Steps

N-tert-Butyl-2-(6-ethyl-1-methyl-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (0.03 g, 0.059 mmol), ethylenediamine (1 mL, 15.0 mmol) and TBAF (1 mL, 3.45 mmol) were combined with DMF (3.0 mL) and the reaction mixture warmed to 60° C. After 3 h, the mixture was concentrated to dryness and partitioned between ethyl acetate and water. The organic phase was concentrated in vacuo then purified by chromatography to give 2-(6-ethyl-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide (5 mg, 22%). MS: (M+H)+=377; 1H NMR (DMSO-d6) δ: 12.79 (br. s., 1H), 8.96-9.28 (m, 1H), 8.19-8.49 (m, 2H), 7.97 (s, 1H), 7.57 (s, 1H), 6.98-7.25 (m, 1H), 4.16 (s, 3H), 2.81 (q, J=7.4 Hz, 2H), 1.41-1.66 (m, 9H), 1.21-1.35 (m, 3H).

Provenance & Evidence