HCID 71280151, compound → HCID 71280551, compound

Participants

Reaction Steps

2-(6-Fluoro-1-methyl-1H-indazol-3-yl)-N-(2,2,3,3,6,9,9,10,10-nonamethyl-4,8-dioxa-3,9-disilaundecan-6-yl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (65 mg, 0.104 mmol) was dissolved in a saturated solution of HCl (g) in dioxane (10 mL). The mixture was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure. The residue was triturated with MeOH then decanted and dried to give N-(1,3-dihydroxy-2-methylpropan-2-yl)-2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (28 mg, 68%).

Provenance & Evidence