Hydrochloric Acid → HCID 71280493, compound

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Reaction Steps

tert-Butyl 2-(2-(6-chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-2-methylpropylcarbamate (0.05 g, 0.1 mmol) in 30 mL of a saturated solution of HCl (g) in dioxane was stirred at room temperature for 2 hours. The solvent was removed and the residue was triturated with ethyl acetate, filtered and filter cake washed with saturated aqueous NaHCO3 and water successively to give N-(1-amino-2-methylpropan-2-yl)-2-(6-chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (22 mg, 55%) as a yellow solid. MS: (M+H)+=398; 1H NMR (300 MHz, DMSO): δ 8.97 (s, 1H), 8.60 (d, 1H, J=8.7 Hz), 8.36 (s, 1H), 7.96 (s, 1H), 7.90 (s, 1H), 7.32 (d, 1H, J=8.7 Hz), 4.17 (s, 3H), 2.90 (s, 2H), 1.30 (s, 6H).

Provenance & Evidence