反应详情

To a stirred solution of 2-amino-2-methylpropan-1-ol (1.78 g, 0.02 mol) in dichloromethane (25 mL) was added tert-butyldimethylsilyl chloride (5.4 g, 0.036 mol) followed by imidazole (3.4 g, 0.05 mol). The mixture was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure. The residue was diluted with water and extracted with EtOAc (3×30 mL). The combined organic layers were washed with NaHCO3 aqueous, brine and dried over Na2SO4. After filtration and concentration, the residue was purified by column chromatography on silica gel eluting with EtOAc to give 1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-amine (3.1 g, 76%) as an oil. 1H NMR (300 MHz, CDCl3): δ 3.26 (s, 2H), 1.02 (s, 6H), 0.88 (s, 9H), 0.03 (s, 6H).

1. customThe solvent was removed under reduced pressure
2. additionThe residue was diluted with water
3. extractionextracted with EtOAc (3×30 mL)
4. washThe combined organic layers were washed with NaHCO3 aqueous, brine
5. dry with materialdried over Na2SO4
6. filtrationAfter filtration and concentration
7. customthe residue was purified by column chromatography on silica gel eluting with EtOAc