1-Methyl-3-(tributylstannyl)-1H-indazole-6-carbonitrile → (2-(6-cyano-1-methyl-1H-indazol-3-yl)-7-(1-hydroxy-2-methylpropan-2-ylcarbamoyl)-5H-pyrrolo[2,3-b]pyrazin-5-yl)methyl pivalate

Participants

Reaction Conditions

Reaction Steps

In a round-bottomed flask, (2-bromo-7-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-ylcarbamoyl)-5H-pyrrolo[3,2-b]pyrazin-5-yl)methyl pivalate (305 mg, 0.565 mmol) and a crude mixture of 1-methyl-3-(tributylstannyl)-1H-indazole-6-carbonitrile and 1-methyl-3-(tributylstannyl)-1H-indazole-6-carbonitrile were dissolved in DMF (5 mL) under nitrogen. Pd (PPh3)4 (32 mg, 0.028 mmol) and CuI (21 mg, 0.113 mmol) were added and mixture was sonicated for 5 minutes while bubbling nitrogen. The reaction mixture was stirred at 80° C. for 16 hours. The concentrated mixture was purified by column chromatography on silica gel eluting with petroleum ether/EtOAc (1:1, v/v) to give (2-(6-cyano-1-methyl-1H-indazol-3-yl)-7-(1-hydroxy-2-methylpropan-2-ylcarbamoyl)-5H-pyrrolo[2,3-b]pyrazin-5-yl)methyl pivalate (45 mg, 16%). MS: (M+H)+=504.

Provenance & Evidence