反应详情

A mixture of 2-(6-chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (0.07 g, 0.3 mmol), 2-amino-2-methylpropanenitrile hydrochloride (0.05 g, 0.42 mmol), EDCI (0.057 g, 0.3 mmol), DMAP (0.037 g, 0.3 mmol), and DIPEA (0.163 g, 1.26 mmol) in 10 mL of DMF were stirred at room temperature for 5 hours. Then HATU (0.114 g, 0.3 mmol) was added, the final reaction mixture was stirred for additional 15 hours. The solvent was removed under reduced pressure at 70° C., then the residue was triturated with water and ethyl acetate successively then decanted and dried to give 2-(6-chloro-1-methyl-1H-indazol-3-yl)-N-(2-cyanopropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (0.026 g, 31%) as a white solid.

1. customthe final reaction mixture
2. stirringwas stirred for additional 15 hours
3. customThe solvent was removed under reduced pressure at 70° C.
4. customthe residue was triturated with water and ethyl acetate successively
5. customdecanted
6. customdried