Potassium Hydroxide → HCID 71280375, compound

Participants

Reaction Steps

A mixture of methyl 2-(1-methyl-1H-indazol-3-yl)-5-(pivaloyloxymethyl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxylate (150 mg, 0.36 mmol), potassium hydroxide (280 mg, 5 mmol) in 2.5 mL of water and 5 mL of 1,4-dioxane was heated to reflux for 90 mins. The reaction mixture was cooled to room temperature, evaporated, acidified with 1N HCl, then filtered and dried to give 2-(1-methyl-1H-indazol-3-yl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid (120 mg, crude) as a brown solid. LCMS: (M+H)+=294. Used into the next step without further purification.

Provenance & Evidence