HRID24663

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCN(C(=O)OC(C)(C)C)c1cc(OC)c(B(O)O)c(OC)c1

HCID22571672

未命名化合物

结构：COC(=O)[C@H](Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1)NC(=O)c1c(Cl)cccc1Cl

HCID22970630

未命名化合物

PRODUCTS

生成物

结构：C=CCN(C(=O)OC(C)(C)C)c1cc(OC)c(-c2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)OC)cc2)c(OC)c1

HCID53992170

未命名化合物

PROCEDURE

实验过程

4-(N-Allyl-N-tert-butoxycarbonylamino)-2,6-dimethoxybenzeneboronic acid and N-(2,6-dichlorobenzoyl)-O-(trifluoromethanesulfonyl)-L-tyrosine methyl ester were coupled by a similar method as described in Example 7-2) to give N-(2,6-dichlorobenzoyl)-4-[4-(N-allyl-N-tert-butoxycarbonylamino)-2,6-dimethoxyphenyl]-L-phenylalanine methyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-32674d330b0f41b6944430d5783eea59
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855843B2
来源说明: uspto-grants-2005_02

反应 SMILES

[CH2:1]([N:4]([C:12]1[CH:17]=[C:16]([O:18][CH3:19])[C:15](B(O)O)=[C:14]([O:23][CH3:24])[CH:13]=1)[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6])[CH:2]=[CH2:3].[CH3:25][O:26][C:27](=[O:55])[C@H:28]([CH2:40][C:41]1[CH:46]=[CH:45][C:44](OS(C(F)(F)F)(=O)=O)=[CH:43][CH:42]=1)[NH:29][C:30](=[O:39])[C:31]1[C:36]([Cl:37])=[CH:35][CH:34]=[CH:33][C:32]=1[Cl:38]>>[CH3:25][O:26][C:27](=[O:55])[C@H:28]([CH2:40][C:41]1[CH:42]=[CH:43][C:44]([C:15]2[C:16]([O:18][CH3:19])=[CH:17][C:12]([N:4]([CH2:1][CH:2]=[CH2:3])[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6])=[CH:13][C:14]=2[O:23][CH3:24])=[CH:45][CH:46]=1)[NH:29][C:30](=[O:39])[C:31]1[C:32]([Cl:38])=[CH:33][CH:34]=[CH:35][C:36]=1[Cl:37]